… Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione
deficiency. Molecular … Glutathione levels modulate domoic acid induced apoptosis in mouse …

… leads to striatal dopaminergic deficiency, and formation of … apoptotic cell death in cerebellar
granule neurons (CGNs) and … PD cellular model, to show the long-term neurotoxic effects of …

… used primary cultures of cerebellar neurons to test whether … cultures to be a very convenient
experimental model to investigate … Domoic acid neurotoxicity was completely prevented by …

… ), and antioxidants (eg, glutathione). While glutamate is most well … names match their
corresponding genes. It is therefore … may help to explain its increased neurotoxicity. Additionally, …

… Neurotoxicity of domoic acid in cerebellar granule neurons in a genetic model of glutathione
deficiency… enhances vulnerability of cultured cerebellar neurons to domoic acid via sodium-…

… The proposed AOP is relevant to adult neurotoxicity testing. A … empirical support describing
(1) domoic acid (DomA) induced … stimuli to genetic changes by regulating gene transcription …

… elegans), a classical model organism used in biomedical … to be a sensitive endpoint for
neurotoxicity, which is consistent with … We thank the Caenorhabditis Genetics Center for providing …

… Genes that code for cytochrome P450 enzymes, glutathione S… role against glutamate
neurotoxicity in neural tissues [60,61], … (cerebral, pedal, and parietovisceral ganglia) of P. …

… , through domoic acid-induced glutamate release (Giordano et al., 2006, Giordano et al.,
2007). Co-exposure to domoic acid and BDE-47 may thus lead to additive neurotoxicity. …

… Domoic acid (DA) is one of the best known marine toxins, causative of important neurotoxic
… indicating by upregulation of Nrf2 and its downstream genes (such as NQO1and HO-1) and …